Margaret was the daughter of unknown parents. The date and place of her birth have not been found.
Her husband was Humphry Hotchkiss. They were married, but the date and place have not been found. Their six known children were Frances (c1638-?), Humphrey (c1639-?), Roger (c1641-?), William (c1643-?), John (c1645-?) and Margery (c1650-?).